Fig. 1 · Structure
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NF764
CTNNB1 Degrader
NF764 is a selective degrader of β-catenin (CTNNB1) that induces its degradation through a proteasome-dependent mechanism. By effectively lowering CTNNB1 protein levels, NF764 serves as a valuable tool for investigating the role of β-catenin in various cancer signaling pathways. This compound is essential for research aimed at understanding tumorigenesis and developing targeted cancer therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3083634-54-9 |
| Applications | CTNNB1 Degrader |
| Formula | C22H20F3NO3 |
| Molecular Weight | 403.39 |
| SMILES | FC(F)(F)C1=C(C2N(C(/C=C/C(C3=CC=CC=C3)=O)=O)CCC2)C=C(OC)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.