NG-nitro-L-arginine is a potent nitric oxide synthase (NOS) inhibitor, demonstrating inhibitory constants (Kis) of 0.61 μM for neuronal NOS (nNOS), 4.28 μM for inducible NOS (iNOS), and 0.72 μM for endothelial NOS (eNOS). This compound effectively inhibits the formation and release of endothelium-derived relaxing factor (EDRF), making it a valuable tool in cardiovascular research. NG-nitro-L-arginine has been shown to reduce portal-systemic shunting in portal-hypertensive rat models and is associated with increased blood pressure, thereby serving as a key reagent for studies investigating vascular function and regulation.
NG-nitro-L-arginine is a potent nitric oxide synthase (NOS) inhibitor, demonstrating inhibitory constants (Kis) of 0.61 μM for neuronal NOS (nNOS), 4.28 μM for inducible NOS (iNOS), and 0.72 μM for endothelial NOS (eNOS). This compound effectively inhibits the formation and release of endothelium-derived relaxing factor (EDRF), making it a valuable tool in cardiovascular research. NG-nitro-L-arginine has been shown to reduce portal-systemic shunting in portal-hypertensive rat models and is associated with increased blood pressure, thereby serving as a key reagent for studies investigating vascular function and regulation.
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