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NGD 94-1 dimaleate

Dopamine D4 Receptor Antagonist

NGD 94-1 dimaleate is a selective antagonist targeting the dopamine D4 receptor, demonstrating a high affinity for the cloned human D4.2 receptor with a Ki value of 3.6 nM. This compound modulates cognitive functions within the frontostriatal system and effectively regulates dopaminergic transmission in models of Phencyclidine (PCP)-induced behavior. NGD 94-1 dimaleate is a valuable tool for research focused on neurological diseases and disorders involving dopaminergic signaling.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	179333-18-7
Applications	Dopamine D4 Receptor Antagonist
Formula	C₂₆H₂₈N₆O₈
Molecular Weight	552.54
SMILES	O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.C1(N2CCN(CC3=CN=C(C4=CC=CC=C4)N3)CC2)=NC=CC=N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.