NGD9002 free base is a selective antagonist of the corticotropin-releasing factor-1 (CRF-1) receptor, primarily targeting adrenergic receptors. It demonstrates significant inhibitory activity on CRF-induced colonic function stimulation, reducing fecal output responses with an IC50 value of 4.3 mg/kg. NGD9002 free base effectively blocks CRF-induced colonic secretory motility and mitigates acute water avoidance-induced defecation, while also preventing pain hypersensitivity reactions associated with repeated colonic distension. This compound is valuable for research into stress-related gastrointestinal disorders and the role of CRF in gut function.
NGD9002 free base is a selective antagonist of the corticotropin-releasing factor-1 (CRF-1) receptor, primarily targeting adrenergic receptors. It demonstrates significant inhibitory activity on CRF-induced colonic function stimulation, reducing fecal output responses with an IC50 value of 4.3 mg/kg. NGD9002 free base effectively blocks CRF-induced colonic secretory motility and mitigates acute water avoidance-induced defecation, while also preventing pain hypersensitivity reactions associated with repeated colonic distension. This compound is valuable for research into stress-related gastrointestinal disorders and the role of CRF in gut function.
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