Fig. 1 · Structure
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NGD94-1
Dopamine D4 Receptor Antagonist
NGD94-1 is a potent and selective antagonist of the dopamine D4 receptor, exhibiting high affinity for the human D4.2 receptor (Ki = 3.6 nM). This compound plays a significant role in modulating cognitive functions within the frontostriatal system and regulates dopaminergic transmission, particularly in Phencyclidine (PCP)-induced models. NGD94-1 is suitable for applications in neurological disease research, providing valuable insights into dopaminergic mechanisms and their impact on cognition.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 178928-68-2 |
| Applications | Dopamine D4 Receptor Antagonist |
| Formula | C18H20N6 |
| Molecular Weight | 320.39 |
| SMILES | C1(N2CCN(CC3=CN=C(C4=CC=CC=C4)N3)CC2)=NC=CC=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.