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NI-Pano

KDAC Inhibitor

NI-Pano (CH-03) is a hypoxia-activated inhibitor of lysine deacetylases (KDACs). This compound is bioreductively activated in an oxygen-dependent manner, leading to the release of the pharmacologically active agent panobinostat. NI-Pano (CH-03) displays significant potential for cancer research, particularly in studies focused on the effects of hypoxic tumor microenvironments and the modulation of epigenetic regulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2733559-66-3
Applications	KDAC Inhibitor
Formula	C₂₆H₂₈N₆O₄
Molecular Weight	488.54
SMILES	CC(N1)=C(CCNCC2=CC=C(/C=C/C(NOCC3=CN=C([N+]([O-])=O)N3C)=O)C=C2)C4=C1C=CC=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.