Fig. 1 · Structure

Cat. No.: A10640
CAS No.: 59-67-6
Formula: C₆H₅NO₂
Mol. Weight: 123.11

Documents & Downloads

Other Forms

Form	MW
Niacin This page	123.11
Niacin hydrochloride	159.57

Niacin

B3 vitamin

Niacin (Vitamin B3) is a vital water-soluble vitamin that functions primarily as a coenzyme in energy metabolism. It is crucial for NAD+ and NADP+ synthesis, which are essential for various cellular processes, including gene expression and apoptosis. Niacin is widely utilized in the research of cardiovascular diseases and metabolic disorders, highlighting its importance in understanding human health and disease mechanisms.

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In Vitro Studies

Niacin was evaluated in NCI-h716 cells using PYY expression as the readout. Incubation with Niacin did not induce a significant increase in PYY expression. [1]

Literature-reported observations and conditions; not Adooq-tested protocols or general treatment recommendations.

Niacin and PYY Expression in Cultured Cells

Cell-based study · NCI-h716 cells [1]

In NCI-h716 cells, incubation with Niacin did not induce a significant increase in PYY expression.

Measured endpoints — not treatment concentrations
Endpoint	Reported result	Reference
PYY expression	Reported result 24 h incubation; niacin (GPR109a, 1 mM): Only the FFA2 agonist, tiglic acid, but not FFA3 or GPR109a agonists (1-methylcyclopropane carboxylate (1-MCPC) and niacin, respectively), induced a significant increase of PYY expression.	[1]

Literature-Reported Treatment Conditions

Treatment concentration: 1 mM
Exposure duration: 24 h
Method: incubation
Vehicle: water

Methods and source locations

Compound reported in the paper: Niacin

Literature evidence for the named compound in the stated model; no Adooq product-use or lot-performance claim.

Results > Mechanisms involved in the effects of SCFAs (S16); Material and Methods > Cell culture and reagents (S51); Figure 2 legend (S91, S97)

PYY expression: PYY expression; comparator: control — Results > Mechanisms involved in the effects of SCFAs (S16); Figure 2 legend (S91)

Specifications

Manufacturer	Adooq Bioscience
CAS Number	59-67-6
Applications	B3 vitamin
Formula	C₆H₅NO₂
Molecular Weight	123.11
Synonyms	Nicotinic acid; Vitamin B3
SMILES	O=C(C1=CC=CN=C1)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Research References

[1] Larraufie P, Martin-Gallausiaux C, Lapaque N, et al. SCFAs strongly stimulate PYY production in human enteroendocrine cells. Sci Rep (2018). PMID: 29311617 DOI: 10.1038/s41598-017-18259-0 Source material