Fig. 1 · Structure
Documents & Downloads
Nic-15
Anti-hypovascular Modulator
Nic-15 is an anti-hypovascular modulator that targets the hypovascularity of pancreatic tumors, thereby addressing a key factor that contributes to cancer cell adaptation and drug resistance in nutrient-poor environments. By regulating the PI3K/Akt/mTOR signaling pathway, Nic-15 mitigates ER stress induced by the chemotherapeutic agent Gemcitabine. Additionally, it demonstrates significant inhibition of migration and colony formation in MIA PaCa-2 and PANC-1 pancreatic cancer cells. In preclinical in vivo xenograft studies, the combination of Nic-15 and Gemcitabine notably enhances the therapeutic efficacy against pancreatic tumors, providing a promising strategy to overcome drug resistance.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 2896739-91-4 |
| Applications | Anti-hypovascular Modulator |
| Formula | C25H26F2O3 |
| Molecular Weight | 412.47 |
| SMILES | O=C([C@H]1[C@H](C2=CC=CC(F)=C2F)CC(CC/C=C(C)/C)=CC1)C3=C(O)C=CC=C3O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.