Fig. 1 · Structure
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NIC
Host Invasion Inhibitor
NIC is a host invasion inhibitor that primarily targets the merozoite surface protein 1 (MSP-1), which plays a crucial role in the invasion of host cells by malaria parasites. NIC effectively suppresses the invasion of Plasmodium falciparum and Plasmodium vivax, making it a valuable tool for research into malaria pathogenesis and potential therapeutic interventions. Its unique mechanism of action provides insights into host-parasite interactions, aiding in the development of strategies targeting malaria transmission.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 114773-20-5 |
| Applications | Host Invasion Inhibitor |
| Formula | C15H16ClN3O3 |
| Molecular Weight | 321.76 |
| SMILES | O=CC1=C(N=C(CCCC)N1CC2=CC=C([N+]([O-])=O)C=C2)Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.