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Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has been found to increase mental agility and enhance clarity and perception. It decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells. It has similar vasoactive properties in other areas of the body, particularly the lungs. Nicergoline is used for vascular disorders such as cerebral thrombosis and atherosclerosis, arterial blockages in the limbs, Raynaud's disease, vascular migraines, and retinopathy.
| In vitro | DMSO | 19 mg/mL (39.22 mM) | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.64 mL | 103.22 mL | 206.45 mL |
| 0.5 mM | 4.13 mL | 20.64 mL | 41.29 mL |
| 1 mM | 2.06 mL | 10.32 mL | 20.64 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.13 mL |
*The above data is based on the productmolecular weight 484.386. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A17422 |
|---|---|
| CAS No. | 27848-84-6 |
| Formula | C24H26BrN3O3 |
| M. Wt | 484.386 |
| Purity | >98% |
| Synonyms | Nicergoline, Nicotergoline, Nimergoline, Sermion |
| SMILES | O=C(C1=CC(Br)=CN=C1)OC[[email protected]](C[[email protected]]23OC)CN(C)[[email protected]]3([H])CC4=CN(C)C5=C4C2=CC=C5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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