Fig. 1 · Structure
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Niclosamide olamine
Antihelminthic Agent
Niclosamide olamine is an orally active antihelminthic agent primarily targeting parasitic infections. Additionally, it functions as a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells, demonstrating significant potential in cancer research. Niclosamide olamine also exhibits inhibitory effects on DNA replication in Vero E6 cells, making it a versatile compound for studies in both parasitology and oncology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1420-04-8 |
| Applications | Antihelminthic Agent |
| Formula | C15H15Cl2N3O5 |
| Molecular Weight | 388.20 |
| Synonyms | BAY2353 olamine |
| SMILES | O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2O.NCCO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.