Nicotinamide-15N is a stable isotope-labeled form of Nicotinamide, a derivative of vitamin B3. This compound selectively inhibits SIRT1 and SIRT2 activities, with an IC50 of 2 μM for SIRT2. Nicotinamide-15N enhances cellular levels of NAD+, ATP, and reactive oxygen species (ROS), demonstrating potential for suppressing tumor growth and improving survival rates. Additionally, it exhibits anti-HBV activity, making it valuable for studies in cancer research and viral infections.
Nicotinamide-15N is a stable isotope-labeled form of Nicotinamide, a derivative of vitamin B3. This compound selectively inhibits SIRT1 and SIRT2 activities, with an IC50 of 2 μM for SIRT2. Nicotinamide-15N enhances cellular levels of NAD+, ATP, and reactive oxygen species (ROS), demonstrating potential for suppressing tumor growth and improving survival rates. Additionally, it exhibits anti-HBV activity, making it valuable for studies in cancer research and viral infections.
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