Fig. 1 · Structure
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Nifurpirinol
NTR Substrate
Nifurpirinol is a selective prosubstrate for bacterial nitroreductase (NTR). Upon enzymatic reduction by NTR, it produces cytotoxic metabolites that effectively induce apoptosis in targeted cells. This compound demonstrates the ability to selectively ablate NTR-expressing cell types, including pancreatic β cells, osteoblasts, dopaminergic neurons, and podocytes in transgenic zebrafish models. Nifurpirinol is utilized in regeneration studies and disease modeling, particularly in contexts like focal segmental glomerulosclerosis (FSGS).
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 13411-16-0 |
| Applications | NTR Substrate |
| Formula | C12H10N2O4 |
| Molecular Weight | 246.22 |
| Synonyms | P-7138 |
| SMILES | OCC1=NC(/C=C/C2=CC=C([N+]([O-])=O)O2)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.