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(+)-Niguldipine

Ca2+ Channel/α₁-adrenoceptor Inhibitor

(+-Niguldipine is a potent dual inhibitor of L-type Ca2+ channels and α₁-adrenoceptors, exhibiting Ki values of 85 pM and 52 pM, respectively. This compound is significant for studying mechanisms underlying hypertension and cardiovascular diseases, providing valuable insights into the modulation of calcium influx and adrenergic signaling pathways. Researchers can utilize (+)-Niguldipine to explore therapeutic interventions for cardiovascular disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	113165-32-5
Applications	Ca2+ Channel/α₁-adrenoceptor Inhibitor
Formula	C₃₆H₃₉N₃O₆
Molecular Weight	609.71
SMILES	O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC=CC([N+]([O-])=O)=C2)OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.