Fig. 1 · Structure
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Nilotinib-d3
Stable Isotope
Nilotinib-d3 is a stable isotope-labeled derivative of Nilotinib, which acts as a selective inhibitor of the Bcr-Abl tyrosine kinase. This compound exhibits notable antineoplastic properties, making it valuable in cancer research, particularly for studying chronic myeloid leukemia (CML) and related malignancies. Its deuterium label allows for advanced analytical applications, including pharmacokinetic studies and metabolic profiling of Nilotinib in various biological systems.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1215678-43-5 |
| Applications | Stable Isotope |
| Formula | C28H19D3F3N7O |
| Molecular Weight | 532.53 |
| SMILES | C(F)(F)(F)C=1C=C(C=C(NC(=O)C2=CC(NC=3N=C(C=CN3)C=4C=CC=NC4)=C(C)C=C2)C1)N5C=NC(C([2H])([2H])[2H])=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.