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Ninopterin

Folic Acid Analog

Ninopterin (9-Me-PGA; 9-Methyl PGA) functions as a folic acid analog, designed to inhibit dihydrofolate reductase (DHFR). This compound exhibits significant antiproliferative activity, making it useful in cancer research and studies involving folate metabolism. Its ability to disrupt folate-dependent cellular processes positions Ninopterin as a valuable tool for investigating therapeutic strategies and understanding folate-related diseases.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2179-16-0
Applications	Folic Acid Analog
Formula	C₂₀H₂₁N₇O₆
Molecular Weight	455.42
Synonyms	9-Me-PGA; 9-Methyl PGA
SMILES	O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NC(C2=CNC3=NC(N)=NC(C3=N2)=O)C)C=C1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.