Nintedanib-d3 is a deuterated analogue of Nintedanib, a potent triple angiokinase inhibitor targeting VEGFR1/2/3, FGFR1/2/3, and PDGFRα/β. This compound exhibits IC50 values of 34 nM for VEGFR1, 13 nM for VEGFR2 and 3, 69 nM for FGFR1, 37 nM for FGFR2, 108 nM for FGFR3, and 59 nM and 65 nM for PDGFRα and β, respectively. Nintedanib-d3 is ideal for studies involving metabolic pathways, pharmacokinetics, and isotope labeling in biological research.
Nintedanib-d3 is a deuterated analogue of Nintedanib, a potent triple angiokinase inhibitor targeting VEGFR1/2/3, FGFR1/2/3, and PDGFRα/β. This compound exhibits IC50 values of 34 nM for VEGFR1, 13 nM for VEGFR2 and 3, 69 nM for FGFR1, 37 nM for FGFR2, 108 nM for FGFR3, and 59 nM and 65 nM for PDGFRα and β, respectively. Nintedanib-d3 is ideal for studies involving metabolic pathways, pharmacokinetics, and isotope labeling in biological research.
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