Fig. 1 · Structure
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Nintedanib-d3
Stable Isotope
Nintedanib-d3 is a deuterated analogue of Nintedanib, a potent triple angiokinase inhibitor targeting VEGFR1/2/3, FGFR1/2/3, and PDGFRα/β. This compound exhibits IC50 values of 34 nM for VEGFR1, 13 nM for VEGFR2 and 3, 69 nM for FGFR1, 37 nM for FGFR2, 108 nM for FGFR3, and 59 nM and 65 nM for PDGFRα and β, respectively. Nintedanib-d3 is ideal for studies involving metabolic pathways, pharmacokinetics, and isotope labeling in biological research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1624587-84-3 |
| Applications | Stable Isotope |
| Formula | C31H30D3N5O4 |
| Molecular Weight | 542.64 |
| Synonyms | BIBF 1120-d3 |
| SMILES | O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N(C)C(CN4CCN(C([2H])([2H])[2H])CC4)=O)C=C3)/C5=CC=CC=C5)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.