Fig. 1 · Structure
Documents & Downloads
Nintedanib-d8
Stable Isotope
Nintedanib-d8 is a deuterated form of Nintedanib, a potent triple angiokinase inhibitor targeting VEGFR1/2/3, FGFR1/2/3, and PDGFRα/β. With IC50 values of 34 nM, 13 nM, 69 nM, and 59 nM for these receptors, Nintedanib-d8 serves as a valuable stable isotope for analytical studies. This compound is primarily used in research focusing on angiogenesis and related signaling pathways, assisting in the elucidation of drug metabolism and pharmacokinetics.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1624587-87-6 |
| Applications | Stable Isotope |
| Formula | C31H25D8N5O4 |
| Molecular Weight | 547.67 |
| Synonyms | BIBF 1120-d8 |
| SMILES | CN(C([2H])([2H])C1([2H])[2H])C([2H])([2H])C([2H])([2H])N1CC(N(C)C(C=C2)=CC=C2N/C(C3=CC=CC=C3)=C4C5=CC=C(C(OC)=O)C=C5NC/4=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.