Nintedanib-d8 is a deuterated form of Nintedanib, a potent triple angiokinase inhibitor targeting VEGFR1/2/3, FGFR1/2/3, and PDGFRα/β. With IC50 values of 34 nM, 13 nM, 69 nM, and 59 nM for these receptors, Nintedanib-d8 serves as a valuable stable isotope for analytical studies. This compound is primarily used in research focusing on angiogenesis and related signaling pathways, assisting in the elucidation of drug metabolism and pharmacokinetics.
Nintedanib-d8 is a deuterated form of Nintedanib, a potent triple angiokinase inhibitor targeting VEGFR1/2/3, FGFR1/2/3, and PDGFRα/β. With IC50 values of 34 nM, 13 nM, 69 nM, and 59 nM for these receptors, Nintedanib-d8 serves as a valuable stable isotope for analytical studies. This compound is primarily used in research focusing on angiogenesis and related signaling pathways, assisting in the elucidation of drug metabolism and pharmacokinetics.
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