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Nivatrotamab

Nivatrotamab (Hu3F8-BsAb) is a humanized bispecific antibody targeting both GD2 and CD3 antigens. This dual specificity enables Nivatrotamab to function as a T-cell engager, facilitating the direct interaction between T-cells and GD2-expressing tumor cells. It is primarily utilized in research focused on neuroblastoma, a cancer that commonly arises from neural crest cells in the adrenal glands and can also develop in nerve tissues throughout the body. Nivatrotamab's mechanism of action and its role in recruiting and activating T-cells against GD2-positive cancer cells make it a valuable tool in immuno-oncology research.

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Product Details

Manufacturer Adooq Bioscience
CAS Number 2278244-14-5
Synonyms Hu3F8-BsAb

Storage

Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Customer Questions
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
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