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Nivatrotamab
Nivatrotamab (Hu3F8-BsAb) is a humanized bispecific antibody targeting both GD2 and CD3 antigens. This dual specificity enables Nivatrotamab to function as a T-cell engager, facilitating the direct interaction between T-cells and GD2-expressing tumor cells. It is primarily utilized in research focused on neuroblastoma, a cancer that commonly arises from neural crest cells in the adrenal glands and can also develop in nerve tissues throughout the body. Nivatrotamab's mechanism of action and its role in recruiting and activating T-cells against GD2-positive cancer cells make it a valuable tool in immuno-oncology research.
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Product Details
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2278244-14-5 |
| Synonyms | Hu3F8-BsAb |
Storage
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.