Fig. 1 · Structure
Documents & Downloads
NJH-2-056
DUBTAC
NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) that connects the OTUB1 recruiter EN523 with the cystic fibrosis transmembrane conductance regulator (CFTR) chaperone lumacaftor. This compound enhances the stability and function of CFTR, making it a valuable tool in cystic fibrosis research. NJH-2-056 is particularly useful for studies focused on the modulation of protein degradation pathways and the development of therapeutics aimed at improving CFTR availability and function.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2858812-69-6 |
| Applications | DUBTAC |
| Formula | C41H40F2N6O8 |
| Molecular Weight | 782.79 |
| SMILES | C=CC(N1CCN(C(C1)=O)C2=CC=C(O2)CCC(NCCCNC(C3=CC=CC(C4=NC(NC(C5(CC5)C6=CC=C7OC(F)(OC7=C6)F)=O)=CC=C4C)=C3)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.