Fig. 1 · Structure
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NLS (PKKKRKV)
Nuclear Localization Signal
NLS (PKKKRKV) is a nuclear localization signal derived from the SV40 large T antigen that facilitates the binding of karyophilic proteins to importin α. This peptide enhances nuclear entry, making it a valuable tool in gene transfer research and the study of nucleocytoplasmic transport mechanisms. Its application supports the development of gene therapy and the delivery of therapeutic agents into the nucleus.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 95088-49-6 |
| Applications | Nuclear Localization Signal |
| Formula | C40H78N14O8 |
| Molecular Weight | 883.14 |
| SMILES | [C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@@H]1CCCN1)CCCCN)=O)CCCCN)=O)CCCCN)=O)(C(N[C@H](C(N[C@@H]([C@H](C)C)C(O)=O)=O)CCCCN)=O)CCCNC(=N)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.