NLX-266

Catalog No.: A29794
5-HT1A Receptor Agonist
NLX-266 is a selective 5-HT1A receptor agonist that exhibits biased signaling towards ERK1/2 pathways. This compound demonstrates significant potential in research related to neurodegenerative diseases, particularly Parkinson's disease. Its unique mechanism may facilitate the investigation of receptor-mediated pathways and their implications in disease progression.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionNLX-266 is a selective 5-HT1A receptor agonist that exhibits biased signaling towards ERK1/2 pathways. This compound demonstrates significant potential in research related to neurodegenerative diseases, particularly Parkinson's disease. Its unique mechanism may facilitate the investigation of receptor-mediated pathways and their implications in disease progression.
Product Information
Catalog NumA29794
FormulaC20H21ClF3N3O2
Molecular Weight427.85
CAS Number2170564-20-0
SMILESO=C(C1=CC=C(F)C(Cl)=C1)N2CCC(CNCCOC3=NC=CC(F)=C3)(F)CC2
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