NMS-P626 is a potent inhibitor of the tropomyosin receptor kinase A (TRKA), TRKB, and TRKC, demonstrating IC50 values of 8 nM, 7 nM, and 3 nM, respectively. This compound effectively inhibits the proliferation of KM12 colorectal cancer cells by suppressing the phosphorylation of TPM3-TRKA and disrupting downstream signaling pathways, with an observed IC50 of 19 nM in these cells. NMS-P626 is valuable for research applications focused on colorectal cancer and related signaling mechanisms.
NMS-P626 is a potent inhibitor of the tropomyosin receptor kinase A (TRKA), TRKB, and TRKC, demonstrating IC50 values of 8 nM, 7 nM, and 3 nM, respectively. This compound effectively inhibits the proliferation of KM12 colorectal cancer cells by suppressing the phosphorylation of TPM3-TRKA and disrupting downstream signaling pathways, with an observed IC50 of 19 nM in these cells. NMS-P626 is valuable for research applications focused on colorectal cancer and related signaling mechanisms.
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