Fig. 1 · Structure
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NNC-711
GAT-1 Inhibitor
NNC-711 (NO-711 hydrochloride) is a potent and selective inhibitor of GABA transporter 1 (GAT-1), demonstrating IC50 values of 0.04 µM for human GAT-1 and varying efficacy against other GABA transporters. This compound has been shown to possess anticonvulsant and analgesic effects in vivo, while also exhibiting cognitive enhancement properties. NNC-711 serves as a valuable tool for research into neurological disorders, particularly those involving dysregulated GABAergic signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 145645-62-1 |
| Applications | GAT-1 Inhibitor |
| Formula | C21H23ClN2O3 |
| Molecular Weight | 386.87 |
| Synonyms | NO-711 hydrochloride |
| SMILES | O=C(C1=CCCN(CCO/N=C(C2=CC=CC=C2)\C3=CC=CC=C3)C1)O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.