NNMT-IN-4 is a selective and uncompetitive inhibitor of nicotinamide N-methyltransferase (NNMT) with demonstrated membrane permeability. It exhibits IC50 values of 42 nM in biochemical assays and 38 nM in cell-based assays, indicating potent inhibition. With favorable pharmacokinetic and pharmacodynamic profiles, along with excellent oral bioavailability, NNMT-IN-4 serves as a valuable in vivo chemical probe for NNMT research applications.
NNMT-IN-4 is a selective and uncompetitive inhibitor of nicotinamide N-methyltransferase (NNMT) with demonstrated membrane permeability. It exhibits IC50 values of 42 nM in biochemical assays and 38 nM in cell-based assays, indicating potent inhibition. With favorable pharmacokinetic and pharmacodynamic profiles, along with excellent oral bioavailability, NNMT-IN-4 serves as a valuable in vivo chemical probe for NNMT research applications.
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