Fig. 1 · Structure
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NO-711
γ-aminobutyric acid Inhibitor
NO-711 is a selective inhibitor of γ-aminobutyric acid (GABA) uptake, demonstrating potent activity against synaptosomal (IC50 = 47 nM), neuronal (IC50 = 1238 nM), and glial (IC50 = 636 nM) GABA transport. This compound is valuable for studies exploring the modulation of GABAergic signaling and its implications in neurological disorders. Its mechanism makes NO-711 a useful tool in researching the role of GABA uptake in various biological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 159094-94-7 |
| Applications | γ-aminobutyric acid Inhibitor |
| Formula | C21H22N2O3 |
| Molecular Weight | 350.41 |
| Synonyms | NNC-711 free acid |
| SMILES | O=C(C1=CCCN(CCO/N=C(C2=CC=CC=C2)\C3=CC=CC=C3)C1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.