Fig. 1 · Structure
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NOD2 antagonist 1
NOD2 Antagonist
NOD2 antagonist 1 is a selective antagonist of the NOD2 receptor, exhibiting an IC50 of 5.23 μM. This compound effectively inhibits Muramyl dipeptide (MDP)-induced secretion of IL-8 in THP-1 cells and suppresses the release of pro-inflammatory cytokines, including IL-6, IL-10, and TNF-α in peripheral blood mononuclear cells (PBMCs). NOD2 antagonist 1 is valuable for research into inflammatory pathways and immune response modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2411441-54-6 |
| Applications | NOD2 Antagonist |
| Formula | C26H26N4O3S |
| Molecular Weight | 474.57 |
| SMILES | O=C(NC1=CC2=C(CCC2)C=C1)CN3C4=CC=CC=C4N=C3CCNS(=O)(C5=CC=CC=C5)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.