Fig. 1 · Structure
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Nolatrexed
Antifolate
Nolatrexed is an antifolate agent known for its ability to inhibit dihydrofolate reductase, thereby interfering with nucleic acid synthesis. This compound exhibits significant oral bioavailability and is used in research applications related to cancer therapy and cell proliferation control. While it can safely be administered at specific doses, it is important to note that major toxicities may include gastrointestinal reactions and effects on hematological parameters such as platelets and neutrophils.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 147149-76-6 |
| Applications | Antifolate |
| Formula | C14H12N4OS |
| Molecular Weight | 284.34 |
| Synonyms | AG 337 free base |
| SMILES | O=C1N=C(NC2=CC=C(C)C(SC3=CC=NC=C3)=C12)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.