Fig. 1 · Structure
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Notum-IN-1
Notum Inhibitor
Notum-IN-1 is a selective inhibitor of Notum that effectively disrupts Wnt signaling pathways. This compound demonstrates oral bioavailability and is capable of penetrating the blood-brain barrier, making it a valuable tool for in vivo studies in mouse models. Its primary applications include elucidating the role of Notum in various biological processes and investigating therapeutic strategies for Wnt-related disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 338419-11-7 |
| Applications | Notum Inhibitor |
| Formula | C9H7Cl2N3O |
| Molecular Weight | 244.08 |
| SMILES | OCC1=CN(C2=CC=C(Cl)C(Cl)=C2)N=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.