Documents & Downloads

NP1192

PROTAC NAT10 Degrader

NP1192 is a selective PROTAC degrader targeting NAT10, effectively depleting NAT10 protein levels and inhibiting ac4C modification in cancer cells. This compound disrupts the NAT10/HIF-1α/PD-L1 signaling axis, resulting in dual inhibition of hypoxia-driven glycolysis and immunosuppression, thus enhancing antitumor efficacy. NP1192 is valuable for research applications in ovarian, cervical, and glioblastoma cancers, providing insights into therapeutic strategies involving NAT10 modulation.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2966791-41-1
Applications	PROTAC NAT10 Degrader
Formula	C₃₉H₄₂N₈O₅S
Molecular Weight	734.87
SMILES	N#CC1=CC=C(C=C1)C2=CSC(N(/N=C3CCCC/3)CCCCCCC(N4CCN(CC4)C5=C6C(N(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O)=O)=N2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.