Fig. 1 · Structure
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NP1867
PMS2 Inhibitor
NP1867 is a selective covalent inhibitor of PMS2 that functionally disrupts DNA mismatch repair mechanisms. By inhibiting PMS2, NP1867 enhances immune surveillance, making it a valuable tool for studying cancer immunotherapy. This reagent is particularly relevant for research focusing on colorectal cancer and its associated DNA repair pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2930070-08-7 |
| Applications | PMS2 Inhibitor |
| Formula | C29H37N3O5 |
| Molecular Weight | 507.62 |
| SMILES | CN(C)C/C=C/C(NC1=C2C(CN(C2)C(C3=C(C(C)=C(C=C3O)O)OCC4CCCCC4)=O)=CC=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.