Fig. 1 · Structure
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NPC26
Small Molecule Mitochondrial Disruptors
NPC26 is a small molecule targeting mitochondrial disruption with notable anti-tumor properties. It demonstrates significant anti-proliferative effects and cytotoxicity in colorectal cancer (CRC) cell lines such as HCT-116, DLD-1, and HT-29. NPC26 impairs mitochondrial function by triggering the opening of the mitochondrial permeability transition pore (mPTP) and increasing reactive oxygen species production, which leads to programmed cell death. Additionally, it activates the AMP-activated protein kinase (AMPK) signaling pathway, further contributing to its anti-cancer efficacy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 864860-32-2 |
| Applications | Small Molecule Mitochondrial Disruptors |
| Formula | C19H23N3O5S2 |
| Molecular Weight | 437.53 |
| SMILES | O=C(C1=C(NC(C2=CC=C([N+]([O-])=O)S2)=O)SC3=C1CC(C)(C)NC3(C)C)OCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.