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NPRA agonist-11

Catalog No.: A61962
NPRA/NPR1 Agonist
NPRA agonist-11 is a selective agonist of the natriuretic peptide receptor A (NPRA/NPR1), exhibiting AC50 values of 1.681 μM in humans and 0.989 μM in monkeys. This compound is integral to studies of cardiovascular diseases and may also be applicable in the exploration of related disorders. Its mechanism of action makes it a valuable tool for researchers investigating NPRA signaling pathways and their implications in physiological and pathological contexts.
NPRA agonist-11 3055143-61-5 NPRA/NPR1 Agonist
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionNPRA agonist-11 is a selective agonist of the natriuretic peptide receptor A (NPRA/NPR1), exhibiting AC50 values of 1.681 μM in humans and 0.989 μM in monkeys. This compound is integral to studies of cardiovascular diseases and may also be applicable in the exploration of related disorders. Its mechanism of action makes it a valuable tool for researchers investigating NPRA signaling pathways and their implications in physiological and pathological contexts.
Product Information
Catalog NumA61962
FormulaC37H52FN7O2
Molecular Weight645.85
CAS Number3055143-61-5
SMILESCN(C1=NC(N[C@H](C(C=N2)=CN2C)CN(CCC3)C[C@H]3C)=C(C[C@H](C4=CC(F)=CC=C4)CC5)C5=N1)[C@@H]([C@](CC6)([H])CC[C@H]6C(O)=O)CC
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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GPCR/G Protein > Natriuretic Peptide Receptor (NPR)