Fig. 1 · Structure
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NQO2-IN-1
NQO2 Inhibitor
NQO2-IN-1 is a selective inhibitor of quinone oxidoreductase 2 (NQO2), exhibiting an IC50 of 95 nM. This compound enhances the sensitivity of non-small cell lung cancer (NSCLC) cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by promoting reactive oxygen species (ROS) production and facilitating apoptosis. NQO2-IN-1 serves as a valuable tool in cancer research, particularly in exploring therapeutic strategies against TRAIL-resistant tumors.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2920687-14-3 |
| Applications | NQO2 Inhibitor |
| Formula | C18H18N2O3 |
| Molecular Weight | 310.35 |
| SMILES | NC1=CC(N=C2)=C(C=C1)C=C2C3=CC(OC)=C(OC)C(OC)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.