Fig. 1 · Structure
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Nrf2-ARE/hMAO-B/QR2 modulator 1
Multitarget-directed Ligand
Nrf2-ARE/hMAO-B/QR2 modulator 1 is a resveratrol-based multitarget-directed ligand targeting hMAO-B, NRF2, and QR2 with IC50 values of 8.05, 9.83, and 0.57 μM, respectively. This compound exhibits neuroprotective properties by reducing reactive oxygen species (ROS) production in okadaic acid-treated mouse hippocampal slices. Additionally, Nrf2-ARE/hMAO-B/QR2 modulator 1 contains an alkyne group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool for click chemistry applications in biological research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 3035124-25-2 |
| Applications | Multitarget-directed Ligand |
| Formula | C14H12N2O3 |
| Molecular Weight | 256.26 |
| SMILES | O=C1OC(/C=C/C2=CC=C(OC)C=C2)=NN1CC#C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.