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NS-181

MetAP2 Inhibitor

NS-181 is a selective inhibitor of methionine aminopeptidase 2 (MetAP2), with established efficacy as an antiamebic agent. It functions by disrupting the activity of MetAP2, a crucial protein for the proliferation of Entamoeba histolytica. NS-181 demonstrates significant antiamebic activity, effectively promoting the resolution of amebic liver abscesses. This reagent is valuable for research applications related to amebiasis and its associated complications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3075693-63-6
Applications	MetAP2 Inhibitor
Formula	C₂₄H₂₈O₇
Molecular Weight	428.47
SMILES	O=C(O[C@H](C(CC1)=O)[C@@]([C@@]2(C)O[C@@H]2C/C=C(C)\C)(O)[C@]31CO3)/C=C/C4=CC=CC(O)=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.