Fig. 1 · Structure
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NS3623
hERG1/IKr/Ito Activator
NS3623 is an activator of the human ether-a-go-go-related gene (hERG1/KV11.1) potassium channels. It enhances the IKr and Ito currents, exhibiting significant antiarrhythmic properties. Notably, NS3623 operates through a dual mechanism, acting as an inhibitor of hERG1 channels as well, making it valuable for research in cardiac electrophysiology and arrhythmia treatment strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 343630-41-1 |
| Applications | hERG1/IKr/Ito Activator |
| Formula | C15H10BrF3N6O |
| Molecular Weight | 427.18 |
| SMILES | O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(Br)C=C2C3=NNN=N3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.