Fig. 1 · Structure
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NS3763
GLUK5 Receptor Antagonist
NS3763 is a selective noncompetitive antagonist of the GLUK5 receptor, characterized by an IC50 of 1.6 µM. This compound demonstrates minimal antagonistic effects on GLUK6, AMPA, or NMDA receptors, making it a valuable tool for research focused on modulating GLUK5 signaling pathways. NS3763 can be utilized in studies investigating its role in neurological disorders and other conditions related to glutamate signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 70553-45-6 |
| Applications | GLUK5 Receptor Antagonist |
| Formula | C22H16N2O6 |
| Molecular Weight | 404.37 |
| SMILES | O=C(C1=C(NC(C2=CC=CC=C2)=O)C=C(NC(C3=CC=CC=C3)=O)C(C(O)=O)=C1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.