Fig. 1 · Structure
Documents & Downloads
NS383
ASICs Inhibitor
NS383 is a potent and selective inhibitor of acid-sensing ion channels (ASICs), specifically targeting those containing the 1a and/or 3 subunits. It effectively inhibits H(+)-activated currents in rat homomeric ASIC1a and ASIC3, as well as heteromeric ASIC1a+3, with IC50 values between 0.61 and 2.2 μM. NS383 demonstrates significant potential in research focused on pain mechanisms, as it has been shown to reverse pathological pain-like behaviors, likely through both peripheral and central actions.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 309711-59-9 |
| Applications | ASICs Inhibitor |
| Formula | C19H19N3O2 |
| Molecular Weight | 321.37 |
| SMILES | O=C1NC2=C(CN(CC3)CC)C3=C(C4=CC=CC=C4)C=C2/C1=N/O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.