Fig. 1 · Structure
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NS3861 fumarate
α3β4 nAChR Agonist
NS3861 fumarate is a potent agonist of the heteromeric α3β4 nicotinic acetylcholine receptor (nAChR), exhibiting high affinity with a binding Ki of 0.62 nM. This compound selectively engages with α3β4 nAChRs while also demonstrating varying affinities for other nAChR subtypes, including α3β2 (25 nM), α4β4 (7.8 nM), and α4β2 (55 nM). NS3861 fumarate is primarily used in neurological research to investigate nAChR functions and their roles in neuropharmacology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 216853-60-0 |
| Applications | α3β4 nAChR Agonist |
| Formula | C16H18BrNO4S |
| Molecular Weight | 400.29 |
| SMILES | BrC1=C(C2=CC(CC3)N(C)C3C2)SC=C1.OC(/C=C/C(O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.