NS3861 fumarate is a potent agonist of the heteromeric α3β4 nicotinic acetylcholine receptor (nAChR), exhibiting high affinity with a binding Ki of 0.62 nM. This compound selectively engages with α3β4 nAChRs while also demonstrating varying affinities for other nAChR subtypes, including α3β2 (25 nM), α4β4 (7.8 nM), and α4β2 (55 nM). NS3861 fumarate is primarily used in neurological research to investigate nAChR functions and their roles in neuropharmacology.
NS3861 fumarate is a potent agonist of the heteromeric α3β4 nicotinic acetylcholine receptor (nAChR), exhibiting high affinity with a binding Ki of 0.62 nM. This compound selectively engages with α3β4 nAChRs while also demonstrating varying affinities for other nAChR subtypes, including α3β2 (25 nM), α4β4 (7.8 nM), and α4β2 (55 nM). NS3861 fumarate is primarily used in neurological research to investigate nAChR functions and their roles in neuropharmacology.
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