Fig. 1 · Structure
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NSC 140873
RUNX1-CBFβ Inhibitor
NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. This compound is essential for studies investigating the molecular mechanisms underlying viral infections and leukemia. It is important to note that NSC 140873 possesses an unstable structure and may spontaneously convert to a benzodiazepine (Ro5-3335) in solution, which should be considered when designing experiments.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 106410-13-3 |
| Applications | RUNX1-CBFβ Inhibitor |
| Formula | C13H12ClN3O2 |
| Molecular Weight | 277.71 |
| SMILES | ClC1=CC(C(C2=CC=CN2)=O)=C(NC(CN)=O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.