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NSC 357754

Claudin Inhibitor

NSC 357754 is an inhibitor of Claudin, specifically targeting Claudin-2 and Claudin-15. It has been shown to increase transepithelial electrical resistance in cells while decreasing the permeability of certain cations. This reagent is applicable in research focused on intestinal disorders that involve Claudin-mediated pathways, providing insights into mechanisms of disease and potential therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2938216-28-3
Applications	Claudin Inhibitor
Formula	C₂₆H₂₀N₄O₂
Molecular Weight	420.46
SMILES	N=C(C1=CC2=C(OC(/C=C/C3=CC=C(C4=CC5=CC(C(N)=N)=CC=C5O4)C=C3)=C2)C=C1)N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.