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NSC 57148

Grb7 SH2 Domain Antagonist

NSC 57148 is a selective antagonist of the Grb7 SH2 domain, exhibiting an IC50 value of 1.1 μM. This compound effectively inhibits cancer cell proliferation and migration, making it a valuable tool for investigating Grb7-overexpressing malignancies, including breast and pancreatic cancers. Its targeted action positions NSC 57148 as an important reagent for research into cancer biology and therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	4315-44-0
Applications	Grb7 SH2 Domain Antagonist
Formula	C₂₈H₃₀Cl₂N₆O₂
Molecular Weight	553.48
SMILES	O=C(C1=CC=C(C(NC2=CC=C(C3=NC(CN3)C)C=C2)=O)C=C1)NC4=CC=C(C5=NC(CN5)C)C=C4.Cl.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.