NSC-658497

Catalog No.: A63687
SOS1 Inhibitor
NSC-658497 is a potent inhibitor of the Ras guanine nucleotide exchange factor SOS1. It competitively binds to SOS1, thereby effectively inhibiting the SOS1-Ras interaction and reducing SOS1's guanine nucleotide exchange factor activity in a dose-dependent manner. This compound has demonstrated significant efficacy in suppressing Ras signaling pathways, ultimately leading to a reduction in associated cell proliferation. NSC-658497 is valuable for research in cancer biology and signaling modulation.
Grouped product items
Size Price Stock Qty
25mg
$1,275.00
In stock
50mg
$1,625.00
In stock
100mg
$2,000.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionNSC-658497 is a potent inhibitor of the Ras guanine nucleotide exchange factor SOS1. It competitively binds to SOS1, thereby effectively inhibiting the SOS1-Ras interaction and reducing SOS1's guanine nucleotide exchange factor activity in a dose-dependent manner. This compound has demonstrated significant efficacy in suppressing Ras signaling pathways, ultimately leading to a reduction in associated cell proliferation. NSC-658497 is valuable for research in cancer biology and signaling modulation.
Product Information
Catalog NumA63687
FormulaC20H10N2O6S2
Molecular Weight438.43
CAS Number909197-38-2
SMILESO=C1/C(C(C2=CC=CC=C2O1)=O)=C\N3C(S/C(C3=O)=C\C4=CC=C([N+]([O-])=O)C=C4)=S
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