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NSC127916

Methotrexate Analogue

NSC127916 is a 2,6-diaminopurine analogue of Methotrexate, targeting dihydrofolate reductase. This compound exhibits potent inhibition of folate metabolism, making it valuable for research into antiproliferative effects and potential therapeutic applications in cancer biology. Its structure allows for insights into the mechanism of action related to nucleic acid synthesis and cellular growth regulation.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	27150-04-5
Applications	Methotrexate Analogue
Formula	C₁₉H₂₂N₈O₅
Molecular Weight	442.43
SMILES	O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(N(CC2=NC3=C(N)N=C(N)N=C3N2)C)C=C1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.