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NSC45586

PHLPP1/2 Inhibitor

NSC45586 is a selective inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatases PHLPP1 and PHLPP2. By targeting the PP2C phosphatase domain, NSC45586 effectively activates AKT signaling in neuronal cells. This reagent is valuable for research applications focusing on signal transduction pathways and cellular responses involved in neuroprotection and survival.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	739301-85-0
Applications	PHLPP1/2 Inhibitor
Formula	C₂₀H₁₈N₆O₃
Molecular Weight	390.40
SMILES	O=C(O)C1=CC(/N=N/C2=CC=C(/N=N/C3=CC(C)=C(N)C=C3N)C=C2)=CC=C1O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.