Fig. 1 · Structure
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NSC49652
p75NTR Agonist
NSC49652 is a reversible, orally active agonist of the p75 neurotrophin receptor (p75NTR), also known as NGFR, TNFRSF16, and CD271. This compound selectively targets the transmembrane domain of p75NTR, leading to the induction of apoptosis and a reduction in the viability of melanoma cells. NSC49652 is valuable in research applications related to cancer biology and neurotrophin signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 908563-68-8 |
| Applications | p75NTR Agonist |
| Formula | C14H11NO2 |
| Molecular Weight | 225.24 |
| SMILES | O=C(C1=CC=CC=C1O)/C=C/C2=CC=CN=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.