Fig. 1 · Structure
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NSC745887
Anti-cancer Agent
NSC745887 is a potent inhibitor of DNA topoisomerase cleavage, effectively triggering the caspase-8/9-caspase-3-poly (ADP-ribose) polymerase cascade, which promotes apoptosis in cancer cells. This compound is known to enhance γH2AX expression and induce DNA fragmentation, resulting in significant DNA damage. It serves as a valuable reagent for cancer research, enabling investigations into apoptotic pathways and the role of DNA repair mechanisms in tumor biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 54490-26-5 |
| Applications | Anti-cancer Agent |
| Formula | C16H8N2O2 |
| Molecular Weight | 260.25 |
| SMILES | O=C(C1=CC=C2N=CC=NC2=C1C3=O)C4=C3C=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.