NSD-IN-5 is a selective inhibitor of nuclear receptor-binding SET domain (NSD) proteins, demonstrating IC50 values of 6 nM for NSD1 and <1 nM for NSD2. This compound shows potent inhibitory activity against Avg KMS11 multiple myeloma cells, with an IC50 of 6 nM. NSD-IN-5 is a valuable tool for studying the role of NSD proteins in cancer biology and the therapeutic potential in multiple myeloma research.
Fig. 1 · Structure
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NSD-IN-5
NSD Inhibitor
NSD-IN-5 is a selective inhibitor of nuclear receptor-binding SET domain (NSD) proteins, demonstrating IC50 values of 6 nM for NSD1 and <1 nM for NSD2. This compound shows potent inhibitory activity against Avg KMS11 multiple myeloma cells, with an IC50 of 6 nM. NSD-IN-5 is a valuable tool for studying the role of NSD proteins in cancer biology and the therapeutic potential in multiple myeloma research.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3034213-62-9 |
| Applications | NSD Inhibitor |
| Formula | C26H28F2N8O2 |
| Molecular Weight | 522.55 |
| SMILES | FC(C=C(C(F)=C1)OC)=C1C2=NC=C(N3C[C@](N)(CCC3)C(NC)=O)C(CC4=CN=C5N4C=CN=C5N)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.