Fig. 1 · Structure
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NSD2-IN-1
NSD2-PWWP1 Inhibitor
NSD2-IN-1 is a potent inhibitor of NSD2-PWWP1 (nuclear receptor-binding SET domain 2-PWWP1), demonstrating high selectivity with an IC50 of 0.11 μM. By binding to NSD2-PWWP1, this compound modulates the expression of genes regulated by NSD2, leading to notable biological effects such as apoptosis induction and cell cycle arrest. NSD2-IN-1 is useful for studying the role of NSD2 in cellular processes and its potential implications in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2797183-37-8 |
| Applications | NSD2-PWWP1 Inhibitor |
| Formula | C29H31N5 |
| Molecular Weight | 449.59 |
| SMILES | CN1C=NC(C2=C(C=C(C=C2C)CN3CCC(CC3)N)C)=C1C4=CC=C(C5=C4C=CC=C5)C#N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.